Nonhomologous end joining
| PAG Title | Nonhomologous end joining |
| PAG ID | WAG001448 |
| Type | P |
| Source Link |  KEGG |
| Publication Reference | NA |
| PAG Description | Nonhomologous end joining (NHEJ) elimites D double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded D ends, recruitment of D-PKcs (MRX complex in yeast), processing of ends, and recruitment of the D ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and D ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two D DSBs without the need for sequence homology, and so is error-prone. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 2,757 |
| Information Content | Rich |
| Other IDs | hsa03450 |
| Base PAG ID | WAG001448 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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